Phenotypes for Efnb2 Tg(Tek-cre)12Flv MGI:2176622 MGI Mouse

embryonic lethality during organogenesis, complete penetrance ( J:74909 )

• mutant embryos die by E11

abnormal intersomitic vessel morphology ( J:74909 )

• embryos exhibit an arrest in intersomitic vessel angiogenesis at the primary plexus stage; the vessels appear fused dorsally with little or no branching

abnormal vascular development ( J:74909 )

• vasculature is disorganized and less developed

abnormal angiogenesis ( J:74909 )

• E9.5 mutants exhibit a failure of anterior cardinal vein assembly

• the capillary bed of the head appears dilated and arrested at the primary plexus stage

• embryos exhibit an arrest in intersomitic vessel angiogenesis at the primary plexus stage; the vessels appear fused dorsally with little or no branching

abnormal developmental vascular remodeling ( J:74909 )

• E9.5 mutants exhibit a failure of anterior cardinal vein assembly and remodeling

abnormal vitelline vasculature morphology ( J:74909 )

• yolk sac is a homogeneous capillary bed at E9.5, indicating arrest of artery and vein development at the primary plexus stage

absent myocardial trabeculae ( J:74909 )

• little or no myocardial trabecular extensions by E9

abnormal heart looping ( J:74909 )

• heart looping defects

enlarged heart ( J:74909 )

• hearts are swollen at E9.5

abnormal vitelline vasculature morphology ( J:74909 )

• yolk sac is a homogeneous capillary bed at E9.5, indicating arrest of artery and vein development at the primary plexus stage

embryonic growth arrest ( J:74909 )

• embryos are developmentally less advanced at E9.5

decreased embryo size ( J:74909 )

• evident at E10