Phenotypes for Lepr Tg(Syn1-cre)671Jxm MGI:2176782 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Lepr^tm1Rck/Lepr^tm1.1Rck Tg(Syn1-cre)671Jxm/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lepr^tm1.1Rck mutation (1 available); any Lepr mutation (123 available)
Lepr^tm1Rck mutation (1 available); any Lepr mutation (123 available)
Tg(Syn1-cre)671Jxm mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

increased total body fat amount ( J:72241 )

growth/size/body

abnormal body composition ( J:72241 )

• increased adipose tissue mass and decreased lean tissue mass

increased body weight ( J:72241 )

• observed after 5 weeks of age

homeostasis/metabolism

hyperglycemia ( J:72241 )

• 2.3 fold greater plasma glucose levels in females compared to littermates; males normal

increased circulating insulin level ( J:72241 )

• hyperinsulinemia; 6 fold greater plasma insulin levels in males and 16.1 fold greater levels in females compared to littermates

increased circulating leptin level ( J:72241 )

• 5.8 fold greater in males and 8.3 fold greater in females compared to littermates

liver/biliary system

hepatic steatosis ( J:72241 )

• enlarged liver due to fatty deposits

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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