Phenotypes Associated with This Genotype

Genotype
MGI:2177640

• Allelic Composition: Tfam^tm1Lrsn/Tfam^tm1Lrsn; Tg(Ins2-cre)25Mgn/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased insulin secretion ( J:65522 )

• impaired

abnormal circulating insulin level ( J:65522 )

• decreased blood insulin concentration, onset at 5 week of age

increased insulin sensitivity ( J:65522 )

• onset at 27-33 weeks

endocrine/exocrine glands

absent pancreatic beta cells ( J:65522 )

• normal numbers at 7 weeks, absent at 37 weeks

decreased insulin secretion ( J:65522 )

• impaired

cellular

abnormal mitochondrial morphology ( J:65522 )

decreased mitochondrial DNA content ( J:65522 )

• mitochondrial DNA depletion

abnormal respiratory electron transport chain ( J:65522 )

• respiratory chain dysfunction in pancreatic islets