Phenotypes Associated with This Genotype

Genotype
MGI:2179469

• Allelic Composition: Casp1^tm1Flv/Casp1^tm1Flv; Casp4^del/Casp4^del
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased thymocyte apoptosis ( J:24258 )

• Fas mediated apoptosis in thymocytes is suppressed

impaired neutrophil chemotaxis ( J:124226 )

• following stimulation with monosodium urate (MSU) and calcium pyrophosphate dihydrate (CPPD), neutrophil recruitment is impaired

decreased circulating interferon-gamma level ( J:115310 )

• serum levels are reduced in mice given Il12 daily

abnormal cytokine secretion ( J:24258 )

decreased interferon-gamma secretion ( J:115310 )

• significantly reduced levels of Ifn gamma are induced by Il12 in splenocytes

decreased interleukin-1 alpha secretion ( J:24258 )

• no Il1 alpha is released by monocytes in response to LPS

decreased interleukin-1 beta secretion ( J:24258 )

• no Il1 beta is released by monocytes in response to LPS

decreased interleukin-18 secretion ( J:115310 )

• significantly lower levels of Il18 are released by cultured splenocytes

• Il12 treatment fails to cause increased Il18 release but liver and spleen levels increase comparable to controls

decreased interleukin-6 secretion ( J:24258 )

• secretion by monocytes in response to LPS is reduced

decreased tumor necrosis factor secretion ( J:24258 )

• secretion by monocytes in response to LPS is reduced

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:57101 )

decreased susceptibility to endotoxin shock ( J:43088 )

• 10 fold increase in survival (from 6% in wild-type to 60%) of mice challenged with a high dose of LPS

increased susceptibility to bacterial infection ( J:117251 )

• macrophages infected with Legionella and cultured for 72 hours show a 200-fold increase in bacterial number

renal/urinary system

renal tubular necrosis ( J:69421 )

• reduced after ischemic reperfusion as compared to controls

kidney failure ( J:69421 )

• ischemic acute renal failure is less severe than in controls

homeostasis/metabolism

decreased circulating interferon-gamma level ( J:115310 )

• serum levels are reduced in mice given Il12 daily

hematopoietic system

decreased thymocyte apoptosis ( J:24258 )

• Fas mediated apoptosis in thymocytes is suppressed

impaired neutrophil chemotaxis ( J:124226 )

• following stimulation with monosodium urate (MSU) and calcium pyrophosphate dihydrate (CPPD), neutrophil recruitment is impaired

cellular

decreased thymocyte apoptosis ( J:24258 )

• Fas mediated apoptosis in thymocytes is suppressed

impaired neutrophil chemotaxis ( J:124226 )

• following stimulation with monosodium urate (MSU) and calcium pyrophosphate dihydrate (CPPD), neutrophil recruitment is impaired

endocrine/exocrine glands

decreased thymocyte apoptosis ( J:24258 )

• Fas mediated apoptosis in thymocytes is suppressed