Phenotypes for Casp1 Casp4 Il1r1 MGI:2179470 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Casp1^tm1Flv/Casp1^tm1Flv Casp4^del/Casp4^del Il1r1^tm1Imx/Il1r1^tm1Imx
Genetic Background	involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp1^tm1Flv mutation (2 available); any Casp1 mutation (42 available)
Casp4^del mutation (5 available); any Casp4 mutation (33 available)
Il1r1^tm1Imx mutation (4 available); any Il1r1 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased susceptibility to endotoxin shock ( J:43088 )

• resistance to endotoxin shock induced by high dose lipopolysaccharide (LPS)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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