Analysis Tools
mortality/aging
|
• in some females initiation of labor fails resulting in the death of the female and fetuses in utero
|
|
• Background Sensitivity: at weaning fewer than expected mice survive on a 129S4/SvJae BALB/c background compared to on a 124S4/SvJae C57BL/6 background with both exhibiting decreased survival relative to wild-type mice
|
reproductive system
 |
• most females deliver on E20.5 and some on E21.5 instead of E19.5 as wild-type females do
|
|
|
• female mice have a reduced ability to produce live offspring regardless of genotype to which they are mated
• female mice give birth to normal sized litters that die within the first day after birth regardless of genotype
• Background Sensitivity: female mice with the 129S4/SvJae BALB/c background are most severely affected
|
vision/eye
|
• increased inflammation of the cornea and eyelids is observed on the first day after birth in mice with open eyelids
|
|
• ocular dystrophy is observed in mice whose eyelids were delayed in opening
|
|
• hyperkeratinization and squamous metaplasia of the corneal epithelium is observed during the first day after birth in mice with open eyelids
|
|
• corneal opacification is observed in mice whose eyelids were delayed in opening
|
|
• eyelids that were open at birth and subsequently resealed exhibit a delay in reopening
|
|
• some mice have open eye lids at birth but seal in subsequent days
• Background Sensitivity: fewer mice on the 129S4/SvJae BALB/c background had open eyelids at birth compared to on the 129S4/SvJae C57BL/6 background and no mice on an inbred 129S4/SvJae background had open eyelids at birth
|
homeostasis/metabolism
|
• serum follicle stimulating hormone levels are increased by about 20% relative to in heterozygotes
|
endocrine/exocrine glands
galactostasis
(
J:16995
)
|
|
• maternally dependent fetal death is associated with a failure of milk to be ejected as pups fostered by wild-type mice survive
• milk accumulates in the mammary tissue at day 0.5 after delivery
|
|
|
• at 0.5 days after delivery there is an increase in the glandular to adipose tissue ratio
|
|
|
• at 0.5 days after delivery, vacuolation of the lobules of the mammary gland is observed
|
immune system
|
• increased inflammation of the cornea and eyelids is observed on the first day after birth in mice with open eyelids
|
integument
galactostasis
(
J:16995
)
|
|
• maternally dependent fetal death is associated with a failure of milk to be ejected as pups fostered by wild-type mice survive
• milk accumulates in the mammary tissue at day 0.5 after delivery
|
|
|
• at 0.5 days after delivery there is an increase in the glandular to adipose tissue ratio
|
|
|
• at 0.5 days after delivery, vacuolation of the lobules of the mammary gland is observed
|
behavior/neurological
galactostasis
(
J:16995
)
|
|
• maternally dependent fetal death is associated with a failure of milk to be ejected as pups fostered by wild-type mice survive
• milk accumulates in the mammary tissue at day 0.5 after delivery
|
