Phenotypes Associated with This Genotype

Genotype
MGI:2180322

• Allelic Composition: Sv2a^tm1Sud/Sv2a^tm1Sud; Sv2b^tm1Sud/Sv2b^tm1Sud
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:59180 )

• 50% of animals die in the first few days after birth; the remainder die by P21

behavior/neurological

seizures ( J:59180 )

• age of onset P8; increasing severity and frequency with age

nervous system

nervous system phenotype ( J:59180 )

N • normal brain morphology

seizures ( J:59180 )

• age of onset P8; increasing severity and frequency with age

decreased synaptic depression ( J:59180 )

• reduced short-term synaptic depression; 3-5 fold increase during repetitive stimulation