Phenotypes Associated with This Genotype

Genotype
MGI:2182638

• Allelic Composition: Smad3^tm1Par/Smad3^tm1Par
• Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:49839 )

• Background Sensitivity: decreased life span; more pronounced in the 129/Sv background than in the mixed 129/Sv and C57BL/6 background, but evident in both

neoplasm

increased intestinal adenocarcinoma incidence ( J:49839 )

• Background Sensitivity: penetrance of adenocarcinoma is about 30% on the mixed 129/Sv and C57BL/6 background and 100% on the 129/Sv background

• Background Sensitivity: mutants on the mixed background show greater variability in the time course of tumors and tumors are less aggressive and smaller than in the 129/Sv background

• a wide range of tumors are found within a single mouse, including lesions that appear to be polyps

increased metastatic potential ( J:49839 )

• evidence of metastasis to lymph nodes is seen on the 129/Sv background

growth/size/body

decreased body size ( J:49839 )

• about 20% - 30% smaller than controls

• males exhibit a greater size reduction than females

distended abdomen ( J:49839 )

• due to tumors

reproductive system

abnormal fertility/fecundity ( J:49839 )

• mice are fertile, but have reduced efficacy in producing litters

behavior/neurological

lethargy ( J:49839 )

• as mutants age beyond 18 weeks, they exhibit signs of distress that include lethargy

abnormal posture ( J:49839 )

• abnormal, rounded posture, but no associated skeletal defects

digestive/alimentary system

rectal prolapse ( J:49839 )

• Background Sensitivity: due to tumors; more pronounced on the 129/Sv background than on the mixed 129/Sv and C57BL/6 background, with 75% of mutants showing prolapse by 24 weeks of age

increased intestinal adenocarcinoma incidence ( J:49839 )

• Background Sensitivity: penetrance of adenocarcinoma is about 30% on the mixed 129/Sv and C57BL/6 background and 100% on the 129/Sv background

• Background Sensitivity: mutants on the mixed background show greater variability in the time course of tumors and tumors are less aggressive and smaller than in the 129/Sv background

• a wide range of tumors are found within a single mouse, including lesions that appear to be polyps

intestinal obstruction ( J:49839 )

• due to tumors

integument

ruffled hair ( J:49839 )

• as mutants age beyond 18 weeks, they exhibit signs of distress that include fur-ruffling