Phenotypes Associated with This Genotype

Genotype
MGI:2183035

• Allelic Composition: Csf3r^tm1Link/Csf3r^tm1Link
• Genetic Background: involves: 129X1/SvJ * NIH Black Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal bone marrow cell morphology/development ( J:37618 )

• decreased numbers of mature myeloid cells in bone marrow but normal megakaryocyte levels and overall cellularity is normal

decreased bone marrow cell number ( J:37618 )

• metamyelocytes and granulocyte numbers are reduced 50%

decreased neutrophil cell number ( J:37618 )

• 12% normal levels of circulating neutrophils while other blood cell counts are normal

decreased hematopoietic stem cell number ( J:37618 )

• total numbers of hematopoietic progenitor cells in bone marrow is reduced

abnormal monocyte morphology ( J:37618 )

• higher levels of apoptosis in cultured bone marrow mononuclear cells

decreased monocyte cell number ( J:37618 )

• monocyte numbers in peripheral blood are reduced about 50%

immune system

decreased neutrophil cell number ( J:37618 )

• 12% normal levels of circulating neutrophils while other blood cell counts are normal

abnormal monocyte morphology ( J:37618 )

• higher levels of apoptosis in cultured bone marrow mononuclear cells

decreased monocyte cell number ( J:37618 )

• monocyte numbers in peripheral blood are reduced about 50%