Phenotypes Associated with This Genotype

Genotype
MGI:2384052

• Allelic Composition: Jag1^tm1Grid/Jag1^tm1Grid
• Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:54907 )

• death occurs at approximately E10.5 due to widespread hemorrhages

• normal appearance at E9.5, and widespread necrosis is observed at E11.5

• no defects in somitogenesis are observed

embryo

pale yolk sac ( J:54907 )

• a pale yolk sac is seen at E10.5

abnormal vitelline vascular remodeling ( J:54907 )

• large blood vessels are absent from the yolk sacs

cardiovascular system

abnormal vascular development ( J:54907 )

• the vascular network in the forebrain of mutant embryos is not as well developed as in controls

• large blood vessels of the head have an abnormal appearance and a reduced diameter

• the primary vascular plexus of the yolk sac does not remodel into large blood vessels

hemorrhage ( J:54907 )

• widespread, including embryonic and extraembryonic tissues observed at E10.5