Phenotypes Associated with This Genotype

Genotype
MGI:2384126

• Allelic Composition: C1qa^tm1Mjw/C1qa^tm1Mjw
• Genetic Background: involves: 129P2/Ola * 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:47315 )

• 15% die at 4 - 6 months of age

immune system

increased anti-nuclear antigen antibody level ( J:47315 )

• mutants develop high titers of anti-nuclear antibodies

increased anti-histone antibody level ( J:47315 )

glomerulonephritis ( J:47315 )

• Background Sensitivity: severe proliferative crescentic glomerulonephritis evident in 27% mice with electron-dense immune deposits localized in the subendothelial and subepithelial areas

• Background Sensitivity: striking feature is presence of multiple apoptotic bodies in diseased glomeruli

increased susceptibility to bacterial infection ( J:83712 )

• animals challenged with virulent pneumococci develop bacteremia and pneumonia after passive immunization with human IgG1 or human IgG2 unlike wild-type mice that are protected after immunization

renal/urinary system

increased renal glomerulus apoptosis ( J:47315 )

• among mutants without glomerulonephritis, significantly greater numbers of glomerular apoptotic bodies are seen than in controls

glomerulonephritis ( J:47315 )

• Background Sensitivity: severe proliferative crescentic glomerulonephritis evident in 27% mice with electron-dense immune deposits localized in the subendothelial and subepithelial areas

• Background Sensitivity: striking feature is presence of multiple apoptotic bodies in diseased glomeruli

glomerular crescent ( J:47315 )

• Background Sensitivity: proliferation of cells in Bowman's space forming glomerular crescents

cellular

increased renal glomerulus apoptosis ( J:47315 )

• among mutants without glomerulonephritis, significantly greater numbers of glomerular apoptotic bodies are seen than in controls

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
systemic lupus erythematosus		DOID:9074	OMIM:152700 OMIM:300809 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420	J:47315