Phenotypes Associated with This Genotype

Genotype
MGI:2388917

• Allelic Composition: Nppc^lbab/Nppc^lbab
• Genetic Background: either: (involves: C57BL/6J * PL/J) or PL/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

small testis ( J:79175 )

♂ • one month old homozygous males have exceptionally small testes

growth/size/body

decreased body size ( J:79175 )

• overall smaller body size than their littermates; proportionate dwarfing of all organs with the possible exception of the male reproductive tract

disproportionate dwarf ( J:79175 )

• two mutants examined at 9 weeks of age exhibited a greater long bone: spine proportionality ratio than younger mice, suggesting that the long bones had ceased growing (progressive dwarfism)

limbs/digits/tail

short fibula ( J:79175 )

• long bones are shorter than normal

short tibia ( J:79175 )

• long bones are shorter than normal

short tail ( J:79175 )

• mutants have proportionately shortened tails

reproductive system

reproductive system phenotype ( J:79175 )

N • mature mutant males breed, and testes appear by palpation to be of normal size; testis biopsy of a homozygous male revealed normal sperm heads and many sperm tails

small testis ( J:79175 )

♂ • one month old homozygous males have exceptionally small testes

skeleton

abnormal long bone epiphyseal plate morphology ( J:79175 )

• about 50% of those examined had growth plate abnormalities, while the rest exhibited normal growth plates

• Background Sensitivity: the growth plates are less affected on C57BL/6J than on the original PL/J background

disorganized long bone epiphyseal plate ( J:79175 )

• of those having abnormalities, some showed disorganization of both femoral and tibial growth plates while others of only the femoral growth plates;

decreased length of long bones ( J:79175 )

short fibula ( J:79175 )

• long bones are shorter than normal

short tibia ( J:79175 )

• long bones are shorter than normal