Phenotypes Associated with This Genotype

Genotype
MGI:2447457

• Allelic Composition: Nf2^tm1Tyj/Nf2^tm1Tyj
• Genetic Background: involves: 129S2/SvPas * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, incomplete penetrance ( J:40596 )

• most die between E7.5 and E8.5; underdeveloped structures observed at E6.5

embryo

abnormal developmental patterning ( J:40596 )

abnormal dorsal-ventral axis patterning ( J:40596 )

• abnormal morphology of the visceral endoderm is suggestive of a defect in the establishment of the primary dorsal-ventral axis

failure to gastrulate ( J:40596 )

• gastrulation is not initiated

abnormal embryonic tissue morphology ( J:40596 )

absent mesoderm ( J:40596 )

• mesoderm does not form due to failure of gastrulation

abnormal extraembryonic tissue morphology ( J:40596 )

absent extraembryonic ectoderm ( J:40596 )

abnormal placenta morphology ( J:40596 )

small ectoplacental cone ( J:40596 )

disorganized extraembryonic tissue ( J:40596 )

abnormal visceral endoderm morphology ( J:40596 )

• abnormal visceral endoderm; more than one region of squamous morphology is often seen suggesting a defect in the establishment of the primary embryonic axis