Phenotypes Associated with This Genotype

Genotype
MGI:2447472

• Allelic Composition: Nf2^tm1Gth/Nf2⁺
• Genetic Background: involves: 129P2/OlaHsd * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

increased fibroadenoma incidence ( J:63264 )

• 13% of mice exhibit fibroadenoma in the mammary gland

neoplasm

neoplasm ( J:63264 )

N • mice do not develop schwannoma, meningioma or other NF2-associated tumors

increased fibroadenoma incidence ( J:63264 )

• 13% of mice exhibit fibroadenoma in the mammary gland

osseous metaplasia ( J:63264 )

• mice exhibit osseous metaplasia in the lung, brain, kidney, and nasal mucosa

increased neurofibroma incidence ( J:63264 )

• 6% of mice develop neurofibroma

increased lung adenocarcinoma incidence ( J:63264 )

• in 56% in mice

increased renal carcinoma incidence ( J:63264 )

• 6% of mice develop anaplastic carcinoma in the kidney

increased sarcoma incidence ( J:63264 )

• 13% of mice develop carcino-sarcoma in the mammary gland

increased neurofibrosarcoma incidence ( J:63264 )

• 6% of mice develop neurofibrosarcoma with 2 of 7 metastasizing to the liver

increased osteosarcoma incidence ( J:63264 )

• in 44% of mice

increased mesothelioma incidence ( J:63264 )

• 6% of mice develop mesothelioma

increased osteoma incidence ( J:63264 )

• 50% of mice develop osteoma

integument

increased fibroadenoma incidence ( J:63264 )

• 13% of mice exhibit fibroadenoma in the mammary gland

skeleton

abnormal tooth development ( J:63264 )

• 6% of mice exhibit odontoblastic hyperplasia

increased osteosarcoma incidence ( J:63264 )

• in 44% of mice

increased osteoma incidence ( J:63264 )

• 50% of mice develop osteoma

abnormal osteoblast morphology ( J:63264 )

• osteoblastic hyperplasia in 44% of mice

renal/urinary system

increased renal carcinoma incidence ( J:63264 )

• 6% of mice develop anaplastic carcinoma in the kidney

abnormal renal tubule morphology ( J:63264 )

• 38% of mice exhibit renal tubular cell hyperplasia

respiratory system

increased lung adenocarcinoma incidence ( J:63264 )

• in 56% in mice

nervous system

nervous system phenotype ( J:63264 )

N • mice exhibit normal Schwann cell proliferation

increased neurofibroma incidence ( J:63264 )

• 6% of mice develop neurofibroma

increased neurofibrosarcoma incidence ( J:63264 )

• 6% of mice develop neurofibrosarcoma with 2 of 7 metastasizing to the liver

craniofacial

abnormal tooth development ( J:63264 )

• 6% of mice exhibit odontoblastic hyperplasia

growth/size/body

abnormal tooth development ( J:63264 )

• 6% of mice exhibit odontoblastic hyperplasia