Phenotypes Associated with This Genotype

Genotype
MGI:2447583

• Allelic Composition: Dnmt3l^tm1Enl/Dnmt3l^tm1Enl
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:75938 )

• no viable homozygotes are recovered at birth

embryo

open neural tube ( J:75938 )

• neural tube closure defects are seen in embryos from homozygous females

abnormal chorion morphology ( J:75938 )

• the chorion-placenta is smaller than normal in E9.5 embryos from homozygous females

endocrine/exocrine glands

small testis ( J:75938 )

♂ • adult males have severe hypogonadism by 8 weeks of age

reproductive system

abnormal oogenesis ( J:75938 )

♀ • failure of maternal methylated gene imprinting is seen in homozygous females

small testis ( J:75938 )

♂ • adult males have severe hypogonadism by 8 weeks of age

abnormal spermiogenesis ( J:75938 )

♂ • spermatogonia either failed to differentiate or developed into abnormal spermatocytes

infertility ( J:75938 )

• both sexes are sterile

• embryos from homozygous females die around E10.5

nervous system

open neural tube ( J:75938 )

• neural tube closure defects are seen in embryos from homozygous females

cellular

abnormal oogenesis ( J:75938 )

♀ • failure of maternal methylated gene imprinting is seen in homozygous females