Phenotypes Associated with This Genotype

Genotype
MGI:2449544

• Allelic Composition: F8^tm1Kaz/Y
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:24941 , J:36698 )

♂ • mice exhibit a reduced ability to clot blood upon tail cutting, with most animals dying within 2 hours of tail snipping unless cauterized (J:24941)

♂ • 2/3 males die within 2 hours of tail snipping from excessive bleeding (J:36698)

homeostasis/metabolism

abnormal blood coagulation ( J:24941 , J:36698 )

♂ • male hemizygous mice exhibit hemophilia (J:24941)

♂ • mice exhibit a reduced ability to clot blood upon tail cutting, with most animals dying within 2 hours of tail snipping unless cauterized (J:24941)

♂ • plasma from mutant mice exhibits a prolonged clotting time compared to controls (J:24941)

♂ • 2/3 males die within 2 hours of tail snipping from excessive bleeding (J:36698)

hematopoietic system

hematopoietic system phenotype ( J:24941 , J:36698 )

♂N • no spontaneous bleeding is observed into joints or soft tissues up to 12 weeks of age (J:24941)

♂N • males exhibit no spontaneous bleeding, illness or reduction in activity up to 1 year of age (J:36698)

immune system

abnormal immune tolerance ( J:178969 )

♂ • mutants develop anti-factor VIII antibodies following administration of factor VIII

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
factor VIII deficiency		DOID:12134	OMIM:306700	J:24941