Phenotypes Associated with This Genotype

Genotype
MGI:2449982

• Allelic Composition: Rxra^tm1Krc/Rxra⁺; Tg(Pbsn-cre)4Prb/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal prostate gland branching morphogenesis ( J:78553 )

♂ • branching morphogenesis of the prostate ductal system is increased 54% and 52% in the lateral prostate and anterior prostate, respectively

prostate gland epithelial hyperplasia ( J:78553 )

♂ • prostate hyperplasia after 11 months of age

increased prostate intraepithelial neoplasia incidence ( J:78553 )

♂ • low grade prostatic intraepithelial neoplasia after 14 months of age

♂ • after 18 months of age, some animals progress to high grade prostatic intraepithelial neoplasia

endocrine/exocrine glands

abnormal prostate gland branching morphogenesis ( J:78553 )

♂ • branching morphogenesis of the prostate ductal system is increased 54% and 52% in the lateral prostate and anterior prostate, respectively

prostate gland epithelial hyperplasia ( J:78553 )

♂ • prostate hyperplasia after 11 months of age

increased prostate intraepithelial neoplasia incidence ( J:78553 )

♂ • low grade prostatic intraepithelial neoplasia after 14 months of age

♂ • after 18 months of age, some animals progress to high grade prostatic intraepithelial neoplasia

neoplasm

increased prostate intraepithelial neoplasia incidence ( J:78553 )

♂ • low grade prostatic intraepithelial neoplasia after 14 months of age

♂ • after 18 months of age, some animals progress to high grade prostatic intraepithelial neoplasia