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Phenotypes Associated with This Genotype
Genotype
MGI:2449983
Allelic
Composition		 Rxratm1Krc/Rxratm1Krc
Tg(Pbsn-cre)4Prb/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rxratm1Krc mutation (1 available); any Rxra mutation (30 available)
Tg(Pbsn-cre)4Prb mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal prostate gland branching morphogenesis ( J:78553 )
• branching morphogenesis of the prostate ductal system is increased 54% and 52% in the lateral prostate and anterior prostate, respectively
increased prostate intraepithelial neoplasia incidence ( J:78553 )
• 71% incidence of prostatic intraepithelial neoplasia after 4 months of age
• lesions progress to low grade prostatic intraepithelial neoplasia after 5 months of age
• after 10 months of age, some animals progress to high grade prostatic intraepithelial neoplasia
abnormal prostate gland physiology ( J:78553 )
• change in protein profile of secretory proteins
• increase in prostatic cell proliferation rate

endocrine/exocrine glands
abnormal prostate gland branching morphogenesis ( J:78553 )
• branching morphogenesis of the prostate ductal system is increased 54% and 52% in the lateral prostate and anterior prostate, respectively
increased prostate intraepithelial neoplasia incidence ( J:78553 )
• 71% incidence of prostatic intraepithelial neoplasia after 4 months of age
• lesions progress to low grade prostatic intraepithelial neoplasia after 5 months of age
• after 10 months of age, some animals progress to high grade prostatic intraepithelial neoplasia
abnormal prostate gland physiology ( J:78553 )
• change in protein profile of secretory proteins
• increase in prostatic cell proliferation rate

neoplasm
increased prostate intraepithelial neoplasia incidence ( J:78553 )
• 71% incidence of prostatic intraepithelial neoplasia after 4 months of age
• lesions progress to low grade prostatic intraepithelial neoplasia after 5 months of age
• after 10 months of age, some animals progress to high grade prostatic intraepithelial neoplasia

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory