Phenotypes Associated with This Genotype

Genotype
MGI:2450926

• Allelic Composition: Msi1^tm1Okn/Msi1^tm1Okn
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Development of hydrocephalus in postnatal Msi1^tm1Okn/Msi1^tm1Okn mice

mortality/aging

premature death ( J:81794 )

• animals with severe hydroencephaly diplayed death at 1-2 months of age

behavior/neurological

ataxia ( J:81794 )

• animals with severe hydroencephaly diplayed axtaxic gait

cardiovascular system

intracerebral hemorrhage ( J:81794 )

craniofacial

abnormal neurocranium morphology ( J:81794 )

• enlarged, domed cranium

homeostasis/metabolism

dehydration ( J:81794 )

• animals with severe hydroencephaly diplayed dehydration

edema ( J:81794 )

skeleton

abnormal neurocranium morphology ( J:81794 )

• enlarged, domed cranium

nervous system

intracerebral hemorrhage ( J:81794 )

hydrocephaly ( J:81794 )

• by 1-2 weeks of age 70%-80% of animals develop hydroencephaly

dilated lateral ventricle ( J:81794 )

• progressive dilation of lateral ventricles

abnormal corpus callosum morphology ( J:81794 )

• Probst's bundle

abnormal cerebral cortex morphology ( J:81794 )

• thinning of cerebral cortices

abnormal ependyma morphology ( J:81794 )

• abnormal stratification of ependymal cells; abnormal proliferation of ependymal cells