Phenotypes Associated with This Genotype

Genotype
MGI:2451068

• Allelic Composition: Itga1^tm1Gdnr/Itga1^tm1Gdnr
• Genetic Background: involves: 129S4/SvJae * BALB/c

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

increased renal glomerulus apoptosis ( J:91522 )

• increased apoptosis 1 week after treatment with adriamycin

podocyte foot process effacement ( J:91522 )

• increased foot process effacement 1 day after treatment with adriamycin

abnormal renal glomerulus morphology ( J:91522 )

• smaller glomeruli and glomerular tuft area

expanded mesangial matrix ( J:91522 )

• increased mesangial matrix accumulation

• mesangial expansion 1 day after treatment with adriamycin

mesangiolysis ( J:91522 )

• focal mesangiolysis and lesions 1 day after treatment with adriamycin

glomerulosclerosis ( J:91522 )

• increased succeptibility to adriamycin induced kidney damage

• increased glomerular matrix deposition and hyalinosis by 1 week after treatment with adriamycin

• serious interstitial damage and increased apoptosis 1 week after treatment with adriamycin

homeostasis/metabolism

increased circulating creatinine level ( J:91522 )

• abnormally increased creatinine levels as a result of adriamycin treatment

increased circulating serum albumin level ( J:91522 )

• abnormally increased albuminuria as a result of treatment with adriamycin

increased susceptibility to injury ( J:91522 )

• increased susceptibility to glomerulopathy in response to adriamycin-induced kidney injury

cellular

increased renal glomerulus apoptosis ( J:91522 )

• increased apoptosis 1 week after treatment with adriamycin