Phenotypes Associated with This Genotype

Genotype
MGI:2651865

• Allelic Composition: Nr3c1^tm1Ljm/Nr3c1^tm1Ljm
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:81588 , J:82174 )

• all mutants die shortly after birth of respiratory failure (J:81588)

• die within 24 hours of birth (J:82174)

immune system

abnormal thymocyte apoptosis ( J:82174 )

• thymocytes develop normally in vivo, however thymocytes reconstituted into lethally irradiated wild-type mice are resistant to dexamethasone (DEX)-induced apoptosis

• thymocytes are more resistant than wild-type to anti-CD3epsilon-mediated thymocyte apoptosis in vivo due to lack of the prolonged peripheral glucocorticoid surge

respiratory system

abnormal lung morphology ( J:82174 )

• lung hypercellularity

abnormal lung development ( J:82174 )

• poor air space formation

thick pulmonary interalveolar septum ( J:82174 )

respiratory failure ( J:81588 )

hematopoietic system

abnormal thymocyte apoptosis ( J:82174 )

• thymocytes develop normally in vivo, however thymocytes reconstituted into lethally irradiated wild-type mice are resistant to dexamethasone (DEX)-induced apoptosis

• thymocytes are more resistant than wild-type to anti-CD3epsilon-mediated thymocyte apoptosis in vivo due to lack of the prolonged peripheral glucocorticoid surge

cellular

abnormal thymocyte apoptosis ( J:82174 )

• thymocytes develop normally in vivo, however thymocytes reconstituted into lethally irradiated wild-type mice are resistant to dexamethasone (DEX)-induced apoptosis

• thymocytes are more resistant than wild-type to anti-CD3epsilon-mediated thymocyte apoptosis in vivo due to lack of the prolonged peripheral glucocorticoid surge

endocrine/exocrine glands

abnormal thymocyte apoptosis ( J:82174 )

• thymocytes develop normally in vivo, however thymocytes reconstituted into lethally irradiated wild-type mice are resistant to dexamethasone (DEX)-induced apoptosis

• thymocytes are more resistant than wild-type to anti-CD3epsilon-mediated thymocyte apoptosis in vivo due to lack of the prolonged peripheral glucocorticoid surge