Phenotypes Associated with This Genotype

Genotype
MGI:2653193

• Allelic Composition: Pou2af1^tm1Pmt/Pou2af1^tm1Pmt; Ikzf3^tm1Kge/Ikzf3^tm1Kge
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

arrested B cell differentiation ( J:81805 )

• blocked transition from pre-B to immature B cells

absent spleen germinal center ( J:81805 )

• failed to form germinal centers

decreased immunoglobulin level ( J:81805 )

• of all types, relative to wild-type controls

• no development of autoantibodies as seen in Zfpn1a3^tm1Kge mutant mice

decreased IgA level ( J:81805 )

decreased IgD level ( J:81805 )

decreased IgE level ( J:81805 )

decreased IgG level ( J:81805 )

decreased IgM level ( J:81805 )

immune system

arrested B cell differentiation ( J:81805 )

• blocked transition from pre-B to immature B cells

absent spleen germinal center ( J:81805 )

• failed to form germinal centers

decreased immunoglobulin level ( J:81805 )

• of all types, relative to wild-type controls

• no development of autoantibodies as seen in Zfpn1a3^tm1Kge mutant mice

decreased IgA level ( J:81805 )

decreased IgD level ( J:81805 )

decreased IgE level ( J:81805 )

decreased IgG level ( J:81805 )

decreased IgM level ( J:81805 )

renal/urinary system

renal/urinary system phenotype ( J:81805 )

N • histological examination of kidneys showed no inflammation, no glomerular immune complex deposition