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Phenotypes Associated with This Genotype
Genotype
MGI:2653897
Allelic
Composition		 Abl1tm1Mlg/Abl1tm1Mlg
Abl2tm1Ajk/Abl2tm1Ajk
Genetic
Background		 involves: 129S/SvEv * 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abl1tm1Mlg mutation (2 available); any Abl1 mutation (93 available)
Abl2tm1Ajk mutation (0 available); any Abl2 mutation (81 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

nervous system
abnormal neuron differentiation ( J:51887 )
• mutants exhibit delayed appearance of Map2-positive early neurons in the neuroepithelium
abnormal embryonic neuroepithelium morphology ( J:51887 )
• neuroepithelial cells show alterations in actin cytoskeleton
• the neuroepithelium collapses into the lumen of the neural tube at E10.25
delayed neural tube closure ( J:51887 )
• delay of neural tube closure is seen at E9.5, with the neural tube of most embryos closed by E10.25, although in some embryos, gaps remain at one or more fusion points in the head region

cellular
abnormal actin cytoskeleton morphology ( J:51887 )
• neuroepithelial cells show alterations in actin cytoskeleton
increased embryonic tissue cell apoptosis ( J:51887 )
• embryos from E10.5-E11 have massive numbers of apoptotic cells in all tissues of the body
abnormal neuron differentiation ( J:51887 )
• mutants exhibit delayed appearance of Map2-positive early neurons in the neuroepithelium

cardiovascular system

embryo
increased embryonic tissue cell apoptosis ( J:51887 )
• embryos from E10.5-E11 have massive numbers of apoptotic cells in all tissues of the body
abnormal embryonic neuroepithelium morphology ( J:51887 )
• neuroepithelial cells show alterations in actin cytoskeleton
• the neuroepithelium collapses into the lumen of the neural tube at E10.25
delayed neural tube closure ( J:51887 )
• delay of neural tube closure is seen at E9.5, with the neural tube of most embryos closed by E10.25, although in some embryos, gaps remain at one or more fusion points in the head region

homeostasis/metabolism

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory