Phenotypes Associated with This Genotype

Genotype
MGI:2654385

• Allelic Composition: Tg(Myh6-Gnaq)25Gwd/0; Tg(Myh6-Gnaq)40Gwd/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:41949 )

cardiovascular system

enlarged heart ( J:41949 )

• massive enlargement and dilation of all four cardiac chambers

abnormal heart ventricle morphology ( J:41949 )

• ventricles show mild to moderate cellular edema with little or no myocyte loss

dilated cardiomyopathy ( J:41949 )

congestive heart failure ( J:41949 )

• spontaneous cardiac decompensation is seen in 3 of 6 double mutants

respiratory system

increased lung weight ( J:41949 )

• lung/body weight ratio averages 40% more than in controls

pleural effusion ( J:41949 )

• large bilateral pleural effusions

tachypnea ( J:41949 )

• 3 of 6 double mutants become tachypneic between 11 and 14 weeks of age

respiratory distress ( J:41949 )

• 3 of 6 double mutants develop severe respiratory distress between 11 and 14 weeks of age

muscle

dilated cardiomyopathy ( J:41949 )

homeostasis/metabolism

pleural effusion ( J:41949 )

• large bilateral pleural effusions

growth/size/body

enlarged heart ( J:41949 )

• massive enlargement and dilation of all four cardiac chambers

increased lung weight ( J:41949 )

• lung/body weight ratio averages 40% more than in controls