Phenotypes Associated with This Genotype

Genotype
MGI:2654940

• Allelic Composition: Bcl2l1^tm1Tak/Bcl2l1^tm1Tak; Tg(KRT5-cre)1Tak/0
• Genetic Background: involves: C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

decreased keratinocyte adhesion ( J:82661 )

• attachment of isolated keratinocytes to dishes is reduced to about 70% of that of wild-type

increased cellular sensitivity to ultraviolet irradiation ( J:82661 )

• topical application of wortmannin sensitizes the mutant, but not wild-type, skin to UVB-induced apoptosis

increased keratinocyte apoptosis ( J:82661 )

• increase in the number of apoptotic cells in the epidermis

• keratinocytes cultured in vitro exhibit increased incidence of apoptosis in the absence of growth factors

• however, addition of growth factors such as hepatocyte growth factor attenuates the apoptosis

integument

decreased keratinocyte adhesion ( J:82661 )

• attachment of isolated keratinocytes to dishes is reduced to about 70% of that of wild-type

increased keratinocyte apoptosis ( J:82661 )

• increase in the number of apoptotic cells in the epidermis

• keratinocytes cultured in vitro exhibit increased incidence of apoptosis in the absence of growth factors

• however, addition of growth factors such as hepatocyte growth factor attenuates the apoptosis