Phenotypes Associated with This Genotype

Genotype
MGI:2655394

• Allelic Composition: Apoa2^tm1Bres/Apoa2^tm1Bres
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased circulating glucose level ( J:37250 )

• 11% decrease in fasting glucose levels

decreased circulating insulin level ( J:37250 )

• 32% decrease in fasting insulin levels

decreased circulating free fatty acids level ( J:37250 )

• 58% and 32% decrease in fasted and fed FFA levels, respectively

abnormal cholesterol homeostasis ( J:37250 )

• increase in fractional catabolic rate and decrease in transport rate of HDL cholesterol ester

decreased circulating cholesterol level ( J:37250 )

• 67% and 52% reduction in cholesterol levels in fasted and fed state, respectively

decreased circulating HDL cholesterol level ( J:37250 )

• 73% and 64% reduction in HDL cholesterol levels in fasted and fed state, respectively, reduced HDL particle size