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Phenotypes Associated with This Genotype
Genotype
MGI:2656211
Allelic
Composition		 Ceacam1tm1Bcn/Ceacam1tm1Bcn
Genetic
Background		 either: (involves: 129S1/Sv * 129X1/SvJ * BALB/c) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ceacam1tm1Bcn mutation (0 available); any Ceacam1 mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased susceptibility to Coronaviridae infection induced morbidity/mortality ( J:70815 )
• mutants are resistant to mouse hepatitis virus A59 infection and death: they develop fewer and smaller lesions in the liver, titers of virus in the livers are 50-100-fold lower than in contrls and mutants survive a dose 100-fold higher than the lethal dose of virus for wild-type mice

immune system
decreased susceptibility to Coronaviridae infection induced morbidity/mortality ( J:70815 )
• mutants are resistant to mouse hepatitis virus A59 infection and death: they develop fewer and smaller lesions in the liver, titers of virus in the livers are 50-100-fold lower than in contrls and mutants survive a dose 100-fold higher than the lethal dose of virus for wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory