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Phenotypes Associated with This Genotype
Genotype
MGI:2657163
Allelic
Composition		 Dnmt1tm1Enl/Dnmt1tm1Enl
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnmt1tm1Enl mutation (0 available); any Dnmt1 mutation (110 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

nervous system
abnormal neural tube morphology ( J:36234 )
• distorted neural tube observed at E9.5

embryo
embryonic growth arrest ( J:36234 )
• growth is arrested prior to the 8-somite stage
abnormal neural tube morphology ( J:36234 )
• distorted neural tube observed at E9.5
absent somites ( J:36234 )
• lack visible somites at E9.5

cellular
abnormal DNA methylation ( J:36234 )
• DNA of endogenous C-type retroviruses and pericentromeric minor satellite repeats is highly demethylated with methylation level lower than in wild-type or Dnmt1tm1Jae mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/17/2024
MGI 6.24 		The Jackson Laboratory