Phenotypes Associated with This Genotype

Genotype
MGI:2658810

• Allelic Composition: Gdf5^brp/Gdf5^brp
• Genetic Background: involves: NC

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

limbs/digits/tail

abnormal autopod morphology ( J:124813 )

• homozygotes show striking abnormalities of the autopod (manus and pes)

brachypodia ( J:31930 )

• homozygotes exhibit brachypodism, as shown by X-ray photographs of the hindlimbs

abnormal phalanx morphology ( J:124813 )

• either the middle or proximal phalanx is usually lost

brachyphalangia ( J:124813 )

• mutant phalanges excluding the terminal one appear underdeveloped

short humerus ( J:31930 )

short radius ( J:31930 )

short ulna ( J:31930 )

short femur ( J:31930 )

short fibula ( J:31930 )

short tibia ( J:31930 )

abnormal limb development ( J:31930 )

• homozygotes show a modest reduction in the stylopod and zeugopod relative to wild-type controls

short limbs ( J:31930 )

• homozygotes display shortening of all four limbs

growth/size/body

decreased birth weight ( J:31930 )

• at birth, homozygotes display reduced body weights relative to heterozygous controls

decreased body weight ( J:31930 , J:124813 )

• homozygotes display a progressive reduction in body weight relative to heterozygous controls (J:31930)

• at P40 and P60, homozygotes of both sexes are significantly lighter than wild-type controls (J:124813)

skeleton

abnormal phalanx morphology ( J:124813 )

• either the middle or proximal phalanx is usually lost

decreased length of long bones ( J:31930 )

• homozygotes display a modest size reduction in the long bones of the extremities relative to wild-type controls

brachyphalangia ( J:124813 )

• mutant phalanges excluding the terminal one appear underdeveloped

short humerus ( J:31930 )

short radius ( J:31930 )

short ulna ( J:31930 )

short femur ( J:31930 )

short fibula ( J:31930 )

short tibia ( J:31930 )

reproductive system

decreased litter size ( J:124813 )

• homozygotes produce significantly fewer live born pups per litter relative to wild-type controls (5.3 +/- 1.7 vs 6.4 +/- 2.2, respectively)