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Phenotypes Associated with This Genotype
Genotype
MGI:2661219
Allelic
Composition		 Rtn4tm1Matl/Rtn4tm1Matl
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rtn4tm1Matl mutation (1 available); any Rtn4 mutation (131 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal nervous system physiology ( J:83192 )
• myelin from mutants has reduced inhibitory activity in a neurite outgrowth assay in vitro compared to wild-type myelin
• however, mutants are viable, fertile and indistinguishable from wild-type and do not exhibit enhanced regeneration of corticospinal tract axons after spinal cord injury

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory