Phenotypes Associated with This Genotype

Genotype
MGI:2662371

• Allelic Composition: C5ar1^tm1Cge/C5ar1^tm1Cge
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:69177 )

• mutants challenged with Psuedomonas aeruginosa succumb in the second day after challenge while no wild-type mice die

immune system

impaired neutrophil recruitment ( J:69177 )

• when peritoneal inflammation is induced with glycogen in mutants, a decreased number of neutrophils is elicited

abnormal humoral immune response ( J:35529 )

• after injection of chicken egg albumin in the tail and administration of antibodies to egg albumin intratracheally, the null mice exhibit almost complete protection from inflammatory response upon examination of lung tissue

increased susceptibility to bacterial infection ( J:69177 )

• mutants are unable to clear intrapulmonary-instilled Pseudomonas aeruginosa, despite an increase in neutrophil influx, and succumb to pneumonia

• however, mutants are able to clear the bacteria when challenged intraperitoneally

• mutants challenged with a sublethal dose of Pseudomonas become superinfected with secondary bacterial strains

hematopoietic system

impaired neutrophil recruitment ( J:69177 )

• when peritoneal inflammation is induced with glycogen in mutants, a decreased number of neutrophils is elicited