Phenotypes Associated with This Genotype

Genotype
MGI:2663265

• Allelic Composition: Prkaca^tm1Gsm/Prkaca^tm1Gsm
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:77110 )

• influenced by genetic background, with decreased survival associated with increased C57BL/6 contribution

• some mice surviving past weaning

growth/size/body

decreased body weight ( J:77110 )

• 35% reduction in weight at 3 months of age relative to wild-type littermates

postnatal growth retardation ( J:76765 , J:77110 )

• beginning at 2 weeks of age (J:77110)

• normal serum levels of growth hormone (GH) though mice were partially GH resistant (J:77110)

homeostasis/metabolism

decreased urine protein level ( J:77110 )

• reduction in the levels of major urinary proteins

renal/urinary system

decreased urine protein level ( J:77110 )

• reduction in the levels of major urinary proteins

reproductive system

reproductive system phenotype ( J:77110 )

N • full spectrum of male gametes observed indicating normal spermatogenesis

N • normal testicular weight

N • normal sperm count

asthenozoospermia ( J:77110 )

♂ • reduced forward velocity

male infertility ( J:76765 )

♂

cellular

asthenozoospermia ( J:77110 )

♂ • reduced forward velocity