Phenotypes Associated with This Genotype

Genotype
MGI:2664915

• Allelic Composition: Tnfrsf9^tm1Byk/Tnfrsf9^tm1Byk
• Genetic Background: B6.Cg-Tnfrsf9^tm1Byk

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

increased T cell proliferation ( J:83996 )

• proliferation of splenocytes/T-cells is increased compared to wild-type mice when stimulated with anti-CD3 mAb and ConA

abnormal common myeloid progenitor cell morphology ( J:83996 )

• absolute numbers of granulocyte-macrophage, erythroid, and multipotential progenitor cells in the bone marrow, blood, and spleen are higher in mutants than wild-type mice

decreased IgG2a level ( J:83996 )

• 2-3-fold decrease in IgG2a in response to keyhole limpet hemocyanin (KLH) immunization

decreased IgG3 level ( J:83996 )

• 2-3-fold decrease in IgG3 in response to KLH immunization

abnormal cytotoxic T cell physiology ( J:83996 )

• mutants show significantly decreased cytotoxic T lymphocyte activity to vesicular stomatitis virus

immune system

increased T cell proliferation ( J:83996 )

• proliferation of splenocytes/T-cells is increased compared to wild-type mice when stimulated with anti-CD3 mAb and ConA

decreased IgG2a level ( J:83996 )

• 2-3-fold decrease in IgG2a in response to keyhole limpet hemocyanin (KLH) immunization

decreased IgG3 level ( J:83996 )

• 2-3-fold decrease in IgG3 in response to KLH immunization

abnormal cytotoxic T cell physiology ( J:83996 )

• mutants show significantly decreased cytotoxic T lymphocyte activity to vesicular stomatitis virus

decreased interferon-gamma secretion ( J:83996 )

• decrease in IFN-gamma production in response to KLH immunization

• moderate decrease in IFN-gamma secretion from T cells

decreased interleukin-2 secretion ( J:83996 )

• moderate decrease in IL-2 secretion from T cells

decreased interleukin-4 secretion ( J:83996 )

• significant decrease in IL-4 secretion from T cells

cellular

increased T cell proliferation ( J:83996 )

• proliferation of splenocytes/T-cells is increased compared to wild-type mice when stimulated with anti-CD3 mAb and ConA