Phenotypes Associated with This Genotype

Genotype
MGI:2664944

• Allelic Composition: Cd28^tm1Pjl/Cd28^tm1Pjl
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased splenocyte proliferation ( J:83722 )

• splenocytes show increased cellular proliferation compared to wild-type mice when stimulated with anti-CD3 or ConA

abnormal class switch recombination ( J:83722 )

• mutants are incapable of undergoing Ig class switch and fail to mount anti-DNP responses of IgG1, IgG2a and IgM

abnormal immunoglobulin level ( J:83722 )

decreased IgG1 level ( J:83722 )

• naive mutants exhibit decreased IgG1 levels and fail to mount anti-DNP responses of IgG1

decreased IgG2a level ( J:83722 )

• naive mutants exhibit decreased IgG2a levels and fail to mount anti-DNP responses of IgG2a

decreased IgM level ( J:83722 )

• mutants fail to mount anti-DNP responses of IgM and secrete reduced levels of IgM in response to a TD-antigen

abnormal cytotoxic T cell physiology ( J:83722 )

• Vesicular stomatitis virus-specific cytotoxic T lymphocyte responses and plaque reduction neutralizing ability is decreased in mutants

decreased susceptibility to type IV hypersensitivity reaction ( J:83722 )

• mutants exhibit significantly suppressed contact hypersensitivity to FITC and DNFB

decreased interleukin-12 secretion ( J:83722 )

• following ConA stimulation

hematopoietic system

increased splenocyte proliferation ( J:83722 )

• splenocytes show increased cellular proliferation compared to wild-type mice when stimulated with anti-CD3 or ConA

abnormal class switch recombination ( J:83722 )

• mutants are incapable of undergoing Ig class switch and fail to mount anti-DNP responses of IgG1, IgG2a and IgM

abnormal immunoglobulin level ( J:83722 )

decreased IgG1 level ( J:83722 )

• naive mutants exhibit decreased IgG1 levels and fail to mount anti-DNP responses of IgG1

decreased IgG2a level ( J:83722 )

• naive mutants exhibit decreased IgG2a levels and fail to mount anti-DNP responses of IgG2a

decreased IgM level ( J:83722 )

• mutants fail to mount anti-DNP responses of IgM and secrete reduced levels of IgM in response to a TD-antigen

abnormal cytotoxic T cell physiology ( J:83722 )

• Vesicular stomatitis virus-specific cytotoxic T lymphocyte responses and plaque reduction neutralizing ability is decreased in mutants

cellular

increased splenocyte proliferation ( J:83722 )

• splenocytes show increased cellular proliferation compared to wild-type mice when stimulated with anti-CD3 or ConA