mortality/aging
• mice do not survive until birth
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cardiovascular system
• mispositioning of the aorta to the center
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• mispositioning of the entire heart to the left
• no observed defects of the outflow tract septum
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• large defects in the muscular interventricular septum are observed in E13.5 embryos
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• is noted in E13.5 embryos and is accompanied by edema
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