Phenotypes Associated with This Genotype

Genotype
MGI:2672028

• Allelic Composition: Kat2a^tm1Roth/Kat2a^tm1Roth
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:65002 )

• mice die by E10.5

embryo

abnormal mesoderm development ( J:65002 )

• despite normal development of extra-embryonic and cardiac mesoderm, dorsal mesoderm develops abnormally due to an increased in apoptosis

embryonic growth retardation ( J:65002 )

• at E8.5

abnormal chordamesoderm morphology ( J:65002 )

• chordamesoderm develops abnormally

abnormal paraxial mesoderm morphology ( J:65002 )

abnormal head mesenchyme morphology ( J:65002 )

• head mesenchyme develops abnormally

abnormal neural tube morphology ( J:65002 )

• mice rarely form a neural tube

absent notochord ( J:65002 )

• mice rarely form a notochord

absent somites ( J:65002 )

abnormal extraembryonic coelom morphology ( J:65002 )

• ectopic structures form in the exocoelomic cavity projecting from the anterior end

nervous system

abnormal neural tube morphology ( J:65002 )

• mice rarely form a neural tube

growth/size/body

embryonic growth retardation ( J:65002 )

• at E8.5

abnormal head mesenchyme morphology ( J:65002 )

• head mesenchyme develops abnormally