Phenotypes Associated with This Genotype

Genotype
MGI:2672787

• Allelic Composition: Slc6a4^tm1Kpl/Slc6a4^tm1Kpl
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

enhanced conditioned place preference behavior ( J:48275 )

• cocaine-conditioned place preference is significantly enhanced compared to wild-type mice

abnormal sleep pattern ( J:89835 )

• increased REM sleep bouts, more bouts of short duration, and less wake time are seen in mutants compared to wild-type mice

abnormal thermal nociception ( J:81734 )

• no thermal hyperalgesia is seen after unilateral chronic constrictive sciatic nerve injury unlike in wild-type mice

muscle

heart right ventricle hypertrophy ( J:62768 )

• right ventricular hypertrophy is less severe after prolonged hypoxia (2-5 weeks) compared to wild-type mice

cardiovascular system

abnormal pulmonary artery morphology ( J:62768 )

• hypoxia-induced thickening of the distal pulmonary vessels is reduced in mutants compared to wild-type mice

abnormal heart ventricle morphology ( J:62768 )

• left ventricular weight/body weight is lower in mutants

• after 5 weeks under hypoxic conditions right ventricular/left ventricular + septum weight is not increased in mutants unlike in wild-type mice

heart right ventricle hypertrophy ( J:62768 )

• right ventricular hypertrophy is less severe after prolonged hypoxia (2-5 weeks) compared to wild-type mice

increased right ventricle systolic pressure ( J:62768 )

• a greater increase in right ventricular systolic pressure is seen after 5 minutes under hypoxic conditions less than 8% O₂) in mutants compared to wild-type mice

• however prolonged hypoxia (2-5 weeks) produces a smaller increase in right ventricular systolic pressure compared to wild-type

nervous system

abnormal brain morphology ( J:89816 )

• the number of apoptotic cells in the brain is significantly decreased in neonatal mutants

homeostasis/metabolism

decreased serotonin level ( J:62768 )

• whole blood serotonin levels are significantly decreased

growth/size/body

heart right ventricle hypertrophy ( J:62768 )

• right ventricular hypertrophy is less severe after prolonged hypoxia (2-5 weeks) compared to wild-type mice