Phenotypes Associated with This Genotype

Genotype
MGI:2672840

• Allelic Composition: Clec10a^tm1Hed/Clec10a^tm1Hed
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:283174 )

N • normal skin barrier function after exposure to house dust mites (HDMs)

hematopoietic system

increased erythrocyte cell number ( J:78035 )

• homozygotes display a slight but significant (3.5%) increase in red blood cell count relative to wild-type mice

• however, no changes are detected in red cell distribution width, and mutant erythrocyte life spans remain relatively unaffected as determined after biotinylation in vivo

increased hematocrit ( J:78035 )

• homozygotes show a slight but significant (6.0 %) increase in hematocrit levels relative to wild-type mice

increased hemoglobin content ( J:78035 )

• homozygotes show a slight but significant (3.8%) increase in hemoglobin content relative to wild-type mice

decreased mean corpuscular hemoglobin ( J:78035 )

• homozygotes show a slight but significant (1.8%) decrease in mean corpuscular hemoglobin concentration relative to wild-type mice

increased mean corpuscular volume ( J:78035 )

• homozygotes show only a slight (2.4%) increase in mean corpuscular volume relative to wild-type mice

increased neutrophil cell number ( J:283174 )

• increased neutrophil infiltration in skin 6 days after exposure to house dust mites (HDMs)

thrombocytosis ( J:78035 )

• homozygotes show a 13.2% increase in platelet cell number relative to wild-type mice

integument

integument phenotype ( J:283174 )

N • normal skin barrier function after exposure to house dust mites (HDMs)

dermatitis ( J:283174 )

• hypersensitivity to house dust mite (HDM)-induced skin inflammation (erythema, dryness, increased epidermal thickness)

immune system

immune system phenotype ( J:78035 , J:283174 )

N • homozygotes exhibit a normal thymus as well as normal macrophage function and T- and B-cell development relative to control mice (J:78035)

N • in addition, homozygotes show a normal cytotoxic T-cell response to major histocompatibility-disparate P815 tumor cells, with no differences in cytolytic activity, CD8 T cell expansion, and proportion of apoptotic (annexin V⁺) CD8 T cells relative to wild-type control mice (J:78035)

N • normal serum IgE and IgG2c levels after exposure to house dust mites (HDMs) (J:283174)

increased neutrophil cell number ( J:283174 )

• increased neutrophil infiltration in skin 6 days after exposure to house dust mites (HDMs)

dermatitis ( J:283174 )

• hypersensitivity to house dust mite (HDM)-induced skin inflammation (erythema, dryness, increased epidermal thickness)