Phenotypes Associated with This Genotype

Genotype
MGI:2673713

• Allelic Composition: Emx2^tm1Pgr/Emx2^tm1Pgr
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:37631 )

• homozygous animals die shortly after birth

renal/urinary system

absent kidney ( J:37631 )

nervous system

abnormal lateral ventricle morphology ( J:37631 )

• wall of lateral ventricle is shortened; large communication between the two lateral ventricles and the third ventricle

dilated third ventricle ( J:37631 )

• dilation of the choroid plexus of the third ventricle; large communication between the two lateral ventricles and the third ventricle

decreased anterior commissure size ( J:37631 )

• thinner/distorted anterior commissure

abnormal cerebral hemisphere morphology ( J:37631 )

• reduced size of cerebral hemispheres

decreased corpus callosum size ( J:37631 )

• reduced corpus calosum

abnormal Ammon gyrus morphology ( J:37631 )

• reduced size of Ammon's horn

absent dentate gyrus ( J:37631 )

abnormal hippocampal fimbria morphology ( J:37631 )

• severely reduced fimbria

decreased hippocampal fornix size ( J:37631 )

• severely reduced fornix; commissural component of the fornix (hippocampal commisure) was absent or greatly reduced

abnormal cerebral cortex morphology ( J:37631 )

• abnormal cortical structure; alterations of the allocortical structures of the medial wall; medial limbic cortex is reduced

small olfactory bulb ( J:37631 )

• reduced size of the olfactory bulbs