Analysis Tools
mortality/aging
|
• life span of irradiated mice shortened more than normal
|
endocrine/exocrine glands
|
• higher levels of apoptosis seen in thymus
• thymocytes more sensitive to gamma-irradiation
|
 |
• however, male mice are fertile
|
|
|
• disturbed layer of differentiating germ cells and uneven thickness of the germ cell layer at 5 weeks of age
|
growth/size/body
|
• body weight at 1 month is 15-20% lower than normal
|
immune system
|
• higher levels of apoptosis seen in thymus
• thymocytes more sensitive to gamma-irradiation
|
reproductive system
|
|
• however, male mice are fertile
|
|
|
• disturbed layer of differentiating germ cells and uneven thickness of the germ cell layer at 5 weeks of age
|
|
|
• mature sperm reduced 2-3 fold
• enlarged spermatids and multinucleated cells present in the lument of the seminiferous tubules by 5 weeks of age as opposed to 6 months normally
• increased levels of apoptosis
|
hematopoietic system
|
• higher levels of apoptosis seen in thymus
• thymocytes more sensitive to gamma-irradiation
|
cellular
|
|
• mature sperm reduced 2-3 fold
• enlarged spermatids and multinucleated cells present in the lument of the seminiferous tubules by 5 weeks of age as opposed to 6 months normally
• increased levels of apoptosis
|
|
• thymocytes more sensitive to gamma-irradiation
|
