Phenotypes Associated with This Genotype

Genotype
MGI:2674288

• Allelic Composition: Akt1^tm1Mbb/Akt1^tm1Mbb
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:72176 )

• normal numbers of homozygous embryos at E13.5

• by 2-3 weeks after birth, fewer than expected numbers of homozygotes seen

• significant numbers of deaths among homozygotes observed with first three days of life

• survivors were fertile

nervous system

decreased prepulse inhibition ( J:185487 )

• in mice treated with amphetamine

• however, mice exhibit normal prepulse inhibition at baseline or following treatment with MK801

growth/size/body

decreased body weight ( J:72176 )

• 20% reduction in body weight at birth

• at 14 months, homozygous males were only about 75% normal weight

behavior/neurological

behavior/neurological phenotype ( J:185487 )

N • mice exhibit normal startle response

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
schizophrenia		DOID:5419	OMIM:181500	J:185487