Phenotypes Associated with This Genotype

Genotype
MGI:2675312

• Allelic Composition: Smn1^tm1Msd/Smn1^tm1Msd
• Genetic Background: involves: 129P2/OlaHsd * MF1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality before implantation, complete penetrance ( J:42813 )

• massive cell death during early development

cellular

abnormal apoptosis ( J:42813 )

• increased apoptotic cell death at 90 to 100 hours post coitum, relative to wild-type and heterozygous embryos

embryo

embryonic growth retardation ( J:42813 )

• the spherical shape embryos was lost and they appeared shrunken

abnormal embryonic tissue morphology ( J:42813 )

• aberrant development 80 hours post coitum

absent blastocoele ( J:42813 )

• although morula compaction proceeded in most embryos, a blastocoel cavity failed to form and the spherical shape was lost

growth/size/body

embryonic growth retardation ( J:42813 )

• the spherical shape embryos was lost and they appeared shrunken