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Phenotypes Associated with This Genotype
Genotype
MGI:2676138
Allelic
Composition
Lgmntm1Ihn/Lgmntm1Ihn
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lgmntm1Ihn mutation (0 available); any Lgmn mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Enlargement of lysosomes in the kidney-proximal tubule cells of Lgmntm1Ihn/Lgmntm1Ihn mice

growth/size/body
• observed after 20 weeks of age, with mean weights of 50-week old mutants about 80% of those of controls
• initial weight gain is similar to controls, however 20 weeks after weaning, weight increase begins to stagnate and by 50 weeks, mutants weight is about 80% of controls

cellular
• enlarged lysosomes in the kidney proximal tubule cells at 7 months of age

renal/urinary system
• enlarged lysosomes in the kidney proximal tubule cells at 7 months of age


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory