growth/size/body
• observed after 20 weeks of age, with mean weights of 50-week old mutants about 80% of those of controls
|
• initial weight gain is similar to controls, however 20 weeks after weaning, weight increase begins to stagnate and by 50 weeks, mutants weight is about 80% of controls
|
cellular
• enlarged lysosomes in the kidney proximal tubule cells at 7 months of age
|
renal/urinary system
• enlarged lysosomes in the kidney proximal tubule cells at 7 months of age
|