Phenotypes Associated with This Genotype

Genotype
MGI:2676603

• Allelic Composition: Kcnj6^tm1Stf/Kcnj6^tm1Stf; Kcnj9^tm1Kwn/Kcnj9^tm1Kwn
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:77047 )

• between 2 and 8 months due to spontaneous seizures

behavior/neurological

seizures ( J:77047 )

• spontaneous lethal seizures between 2 and 8 months of age

nervous system

seizures ( J:77047 )

• spontaneous lethal seizures between 2 and 8 months of age

abnormal synaptic transmission ( J:77047 )

• resting membrane potentials of locus ceruleus neurons in brain slices are depolarized by 15-20 mV realative to neurons from wild-type mice

• opioid ([Met]⁵ enkephalin)-induced hyperpolarization and whole-cell current is reduced by 80% in locus ceruleus neurons

• the small opioid-sensitive current that is observed in locus ceruleus neurons is eliminated with the nonselective potassium channel blockers barium and cesium