Phenotypes Associated with This Genotype

Genotype
MGI:2677147

• Allelic Composition: Smarca4^tm1.2Pcn/Smarca4^tm1Mag; Tg(Lck-cre)1Cwi/?
• Genetic Background: involves: 129S/Sv * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

thymus hypoplasia ( J:85191 )

• 40-100 fold reduction in cell numbers in the thymus

abnormal T cell differentiation ( J:85191 )

decreased double-negative T cell number ( J:85191 )

decreased double-positive T cell number ( J:85191 )

• absence of double positive T cells

arrested T cell differentiation ( J:85191 )

• T cells become arrested when cre inactivation occurs primarily at DN4 stage but sometimes earlier

• leads to expression of CD4 and to death of T cells

decreased CD4-positive, alpha-beta T cell number ( J:85191 )

• very small numbers of CD4+ cells

absent CD8-positive, alpha-beta T cells ( J:85191 )

• absence of CD8+ cells

immune system

thymus hypoplasia ( J:85191 )

• 40-100 fold reduction in cell numbers in the thymus

abnormal T cell differentiation ( J:85191 )

decreased double-negative T cell number ( J:85191 )

decreased double-positive T cell number ( J:85191 )

• absence of double positive T cells

arrested T cell differentiation ( J:85191 )

• T cells become arrested when cre inactivation occurs primarily at DN4 stage but sometimes earlier

• leads to expression of CD4 and to death of T cells

decreased CD4-positive, alpha-beta T cell number ( J:85191 )

• very small numbers of CD4+ cells

absent CD8-positive, alpha-beta T cells ( J:85191 )

• absence of CD8+ cells

endocrine/exocrine glands

thymus hypoplasia ( J:85191 )

• 40-100 fold reduction in cell numbers in the thymus