behavior/neurological
• circadian amplitude is reduced
• some heterozygotes display elements of free-running even with light cues and the occurrence of this phenotype is not dependent on the presence or absence of Pde6brd1
|
• about 50% of heterozygotes have a period less than 23 hours with the shortest period being 21.5 hours
|
• some heterozygotes display signs of arrhythmicity in constant darkness
|
• some heterozygotes display an abnormal phase angle of entrainment
|
• the phase delay induced by a 15 minute pulse of light at circadian time 16 hours is reduced or absent in some heterozygotes
|
• heterozygotes display incomplete re-entrainment when moved from constant dark back to light-dark cycles
|