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Phenotypes Associated with This Genotype
Genotype
MGI:2679576
Allelic
Composition
Zfhx3Sci/Zfhx3+
Genetic
Background
involves: BALB/cOlaHsd * C3H/HeH
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zfhx3Sci mutation (2 available); any Zfhx3 mutation (130 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• circadian amplitude is reduced
• some heterozygotes display elements of free-running even with light cues and the occurrence of this phenotype is not dependent on the presence or absence of Pde6brd1
• about 50% of heterozygotes have a period less than 23 hours with the shortest period being 21.5 hours
• some heterozygotes display signs of arrhythmicity in constant darkness
• some heterozygotes display an abnormal phase angle of entrainment
• the phase delay induced by a 15 minute pulse of light at circadian time 16 hours is reduced or absent in some heterozygotes
• heterozygotes display incomplete re-entrainment when moved from constant dark back to light-dark cycles


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory