Phenotypes Associated with This Genotype

Genotype
MGI:2679648

• Allelic Composition: Cplx1^tm2Bros/Cplx1^tm2Bros; Cplx2^tm1Bros/Cplx2^tm1Bros
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:86365 , J:136393 )

• die within a few hours of birth (J:86365)

• mice die within a few hours of birth (J:136393)

nervous system

abnormal pre-Botzinger complex physiology ( J:136393 )

• the amplitude of spontaneous excitatory postsynaptic currents are decreased in pre-Botzinger complex neurons compared to in wild-type mice

abnormal neuron physiology ( J:136393 )

• neuron calcium sensitivity of glutamate and GABA release is reduced compared to in wild-type mice

impaired synaptic plasticity ( J:136393 )

• trains of action potentials produce a marked initial facilitation compared to the depression observed in wild-type mice

abnormal CNS synaptic transmission ( J:86365 )

• defect coupling action potential to presynaptic release

• hippocampal EPSC amplitudes reduced 66% but increases with trains of stimuli

• affect is on fast synchronous release

• much less of neurotransmitter released

• decreased Ca+2 sensitivity

decreased excitatory postsynaptic current amplitude ( J:136393 )

• evoked and spontaneous excitatory postsynaptic current amplitudes in hippocampal neurons are reduced compared to in wild-type mice

• the amplitude of spontaneous excitatory postsynaptic currents are decreased in pre-Botzinger complex neurons compared to in wild-type mice

abnormal inhibitory postsynaptic currents ( J:136393 )

• mice exhibit a reduced evoked inhibitory postsynaptic currents and slightly reduced miniature inhibitory postsynaptic currents compared to wild-type mice

• spontaneous miniature inhibitory postsynaptic current frequencies are decreased in hippocampal and pre-Botzinger complex neurons compared to in wild-type mice

decreased miniature excitatory postsynaptic current amplitude ( J:136393 )

• evoked miniature excitatory postsynaptic currents (mEPSCs) are slightly reduced while spontaneous mEPSCs are reduced 30% compared to in wild-type mice

decreased miniature excitatory postsynaptic current frequency ( J:136393 )

• spontaneous mEPSC frequencies are decreased in hippocampal neurons and pre-Botzinger complex neurons compared to in wild-type mice

abnormal neurotransmitter secretion ( J:136393 )

• the probability of vesicular release of the readily releasable pool is reduced 50% compared to in wild-type mice

• neuron calcium sensitivity of glutamate and GABA release is reduced compared to in wild-type mice

• however, the size of the readily releasable pool is normal