Analysis Tools
behavior/neurological
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• reduced exploration in new environment
• less active in open field
• initial higher latency to reach periphery but normal after the first day
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• slower at 8 weeks in the Morris water maze but successful in acquisition and learning new positions, much slower at 1 year
• generally poor in acquisition learning and very poor in reversal learning
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• impaired visual cliff avoidance test, more likely to approach the "cliff" and spend more time there
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• keep whiskers for longer period of time
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• rotarod performance decreases with time, initially normal, poor at 24 weeks
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• pelvis held lower than normal
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tail dragging
(
J:85961
)
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• one third of mice move backward rather than forward when placed in a new environment
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abnormal gait
(
J:85961
)
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• tend not to walk in a straight line, follow a weaving path
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• less rearing activity
• fewer attempts to climb out of cages although strength is normal by hang wire test
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