Phenotypes Associated with This Genotype

Genotype
MGI:2680292

• Allelic Composition: Mapkapk5^tm1Mgl/Mapkapk5^tm1Mgl
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:86268 )

• homozygotes are viable, fertile, and behaviorally normal, with no apparent abnormalities in heart, skeletal and pancreas tissue morphology relative to wild-type littermates

• unlike Mapkapk2^tm1Mgl mutant mice, homozygotes do not exhibit increased resistance to endotoxic shock or decreased LPS-induced biosynthesis of TNF, IL-6, or IFN-gamma in spleen cells but display the same susceptibility to LPS-mediated liver failure as wild-type mice