Phenotypes Associated with This Genotype

Genotype
MGI:2682637

• Allelic Composition: Th^tm1Tna/Th^tm1Tna
• Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * ICR)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:30273 )

• when offspring delivered by Cesarean section are cross-fostered by breeding females, viable homozygotes appear normal within 5-6 hrs after birth but die by P1 without any structural failure in major organs

lethality throughout fetal growth and development, incomplete penetrance ( J:30273 )

• homozygotes are grossly normal up to E12.5; however, 55-57% of embryos die from E14.5 to E16.5 with a variable degree of degradation

perinatal lethality, incomplete penetrance ( J:30273 )

• when delivered by Cesarean section at E18.5, 75% of homozygotes undergo resorption as a consequence of death

• 19% of homozygotes begin to breathe and turned pink within 10 min after birth; however, the remaining 6% die of anoxia within 10 min after birth

homeostasis/metabolism

abnormal adrenaline level ( J:30273 )

• at E12.5, homozygotes show no detectable adrenaline levels

• newborn homozygotes delivered by Cesarean section display very low adrenaline levels in both head and body regions

decreased dopamine level ( J:30273 )

• at E12.5, homozygotes display a dopamine level of 37.5% in the head and 7.7% in the body of wild-type levels

• newborn homozygotes delivered by Cesarean section display a dopamine level of only 23.0% in the head and 41.7% in the body of wild-type levels

abnormal noradrenaline level ( J:30273 )

• at E12.5, homozygotes show no detectable noradrenaline levels

• newborn homozygotes delivered by Cesarean section display very low noradrenaline levels in both head and body regions

anoxia ( J:30273 )

• when delivered by Cesarean section at E18.5, 6% of homozygotes die of anoxia within 10 min after birth

respiratory system

atelectasis ( J:30273 )

• homozygotes dying at birth exhibit atelectasis with no structural blockage in bronchi, bronchioles, and upper respiratory tract; however, signs of degeneration are noted in heart, liver and kidney

respiratory failure ( J:30273 )

• when delivered by Cesarean section at E18.5, 6% of homozygotes fail to breathe and respond poorly to a tapping stimulus

cardiovascular system

decreased heart rate ( J:30273 )

• newborn homozygotes delivered by Cesarean section show significant bradycardia relative to wild-type mice (210 17 bpm vs 307 9 bpm, respectively)

abnormal ST segment ( J:30273 )

• newborn homozygotes delivered by Cesarean section show a slight elevation of the S-T segment; however, no major differences in wave morphology are observed on surface electrocardiograms